MSPO is a general incorporated association that conducts research and development as well as education and training in order to promote advancement of medical safety. In order to achieve this goal, MSPO is organized into the following divisions.
Each division shall establish a board of directors in charge, which shall formulate and maintain internal regulations such as activity guidelines, rules and relevant details.

(Corporate Strategy Division)
　　Functions: Formulate operational methods and missions, and review financial base
　　　　General Manager:　Ryoji Sakai (President of MSPO)
　　　　Office Manager:　Yumi Tobita　tobita.yumi@mspo.org
　　Branch:
　　　　International Cooperation Promotion Department
　　　　Industry-Government-Academia Collaboration Promotion Department
　　　　Information Management Department
　　　　　　Office Manager:　 Yumi Tobita　tobita.yumi@mspo.org
　　　　　　Advisor:　 Ryoji Sakai (President of MSPO)

(Administration Division)
　　Function: Recommend, monitor and implement the standardization and promotion of resource allocation methods
　　　　Office Manager:　 Yumi Tobita　tobita.yumi@mspo.org
　　　　Counselor:　Hiroshi Yotsuyanagi (Director of MSPO)
　　Branch:
　　　　General affairs, human resources, payroll and benefits, materials management, etc.
　　　　Publicity
　　　　Accounting　　Contracted to Shimoda Accounting Office
　　　　　　　　(Address: Kawagoe City, Saitama Prefecture)

(Research & Development Promotion Division)
　　Functions: Plan and review programs, develop standard methods of implementation
　　　　General Manager: Masahisa Fukayama (Advisor of MSPO)
　　　　Counsellor: Hiroshi Yotsuyanagi, (Director of MSPO)
　　　　MSPO Research Institute 　　Director: Hideaki Karaki (Advisor of MSPO)

(Education and Training Promotion Division)
　　Function: Plan and develop programs
　　　　General Manager: Shinichi Izumi
　　　　Counsellor: Hiroshi Yotsuyanagi1 (Director of MSPO)

Directors, Honorary Fellows, Advisors, Professors, Associate Professors, Lecturers, Executive Fellows, Senior Fellows, Research Fellows, Office Directors, Staff, etc.

The status of staff within MSPO is as follows:
The status of the external personnel is that of specially appointed professor, visiting professor, visiting executive fellow, visiting senior fellow and visiting research fellow as listed in the section on industry-government-academia collaboration.

Each position has its own set of professional qualifications, which are assessed by the Corporate Strategy Division. These appointments are made by the Corporate Strategy Division or the Management Division of the organization.